Cheech Marin (Himself)
Tommy Chong (Far Out Man)
Judd Nelson (Himself)
Shelby Chong (Tree)
Paris Chong (Kyle)
C. Thomas Howell (Himself)
Martin Mull (Psychiatrist)
Paul Hertzberg (Drunk Man with Wine)
Floyd Sneed (Drummer in Band)
Guitar Shorty (Himself)
Peggy Sanders (Misty)
Reynaldo Rey (Lou)
Patricia Van Santen (Truck Stop Waitress)
Michael Winslow (Airport Cop)
Don Dokken (Rock Group)
Glenn Wilder (Security Cop)
Patrick Campbell (Clerk)
John Welsh (Driver)
Robbi Chong (Dancer)
Pehelope Jane Reed (Stewardess)
John Norum (Rock Group)
Lisa Hansen (Police Radio Dispatcher)
Peter Ferrara (Rae Dawn's Director)
Tina Fava (Woman with Lou)
Lewis Dix, Jr. (Airport Guard)
Buddy Daniels (Gang Leader)
Rae Dawn Chong (Herself)
Carlos Cervantes (Mexican)
Alina Cenal (Maid)
K. Theodore Howard (Desk Sergeant)
Myra J. (Young Lady)
Paul Murray (Redneck in Cafe)
Mr. Bill (Mr. Bill, the Dog)
Paul Monroe (Rock Group)
Ronnie Tanksley (Nurse)
Terence Kirkland (Hitchhiker)
Henry Kingi (Mean Indian)
Rae Allen (Holly)
Al Mancini (Fresno Detective)
Paul Bartel (Weebee Cool)
Bobby Taylor (Bobby)