Jeff Bridges (James Butler "Wild Bill" Hickok)
Ellen Barkin (Calamity Jane)
John Hurt (Charley Prince)
Diane Lane (Susannah Moore)
David Arquette (Jack McCall)
Keith Carradine (Buffalo Bill Cody)
Luana Anders (Sanitarium Woman)
Merritt Yohnka (Soldier)
Jim Wilkey (Seth Beeber)
James Michael Taylor (Lew Scott)
Boots Southerland (Crook-Eye Clark)
Janel Moloney (Earlene)
Sally Jane Jackson (Hubal Pickett)
Patrick Gorman (Doctor)
Pato Hoffmann (Cheyenne Leader)
James Marsh (Young Man)
Karen Huie (Song Lew)
Robert Knott (Dave Tutt)
Robert Keith (Miner)
Robert Peters (Mike Williams)
Jason Ronard (Pink Buford)
James Remar (Donnie Lonigan)
Steve Reevis (Sioux Chief Whistler)
Bruce Dern (Will Plummer)
Anthony de Longis (Card Cheat)
Lee de Broux (Carl Mann)
Alisa Christensen (Mann's No. 10 Saloon Bargirl)
Steve Chambers (Curly)
Loyd Catlett (Rob Rainwater)
Thomas Wilson Brown (Drover)
Bill Bolender (Bartender at Way Station)
Virgil Frye (Buffalo Hunter)
James Gammon (California Joe)
Burton Gilliam (Bartender)
Ted Markland (Tommy Drum)
John Dennis Johnston (Ed Plummer)
Peter Jason (Dave McCandless)
Lise Hilboldt (Woman in Church)
Dennis Hayden (Phil Coe)
Linda Harrison (Madam)
Charles Gunning (Frank Dowder)
Marjoe Gortner (Preacher)
Christina Applegate (Lurline)