William Simms may refer to:
William Simms (instrument maker) (1793-1860), British astronomical instrument maker,
William E. Simms (1822-1898), U.S. Representative and Confederate Senator from Kentucky,
William Gilmore Simms (1806-1870), 19th-century American writer,
William Simms, 16th-century Irish sailor alleged to have lived at Pikes on Cliffs, Spain,
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