The term upstate often refers to the northerly portions of several U.S. states. It also can refer to parts of states that have a higher elevation, away from sea level. These regions tend to be rural; an exception is Delaware.
On the east coast, "upstate" generally refers to places away from the Atlantic Ocean.
Upstate California was a 2001 marketing campaign to promote the northern half of Northern California,
Maine, except for "Down East",
Upstate New York, an area of New York north of the New York City metropolitan area
SUNY Upstate Medical University, often referred to as "Upstate",
Upstate South Carolina, the northwestern "corner" of South Carolina
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