Mark Holmes may refer to:
Mark V. Holmes (born 1960), United States judge,
Mark Holmes (filmmaker) (born 1968), filmmaker and part owner of Daisy 3 Pictures,
Mark Holmes (canoer),
Mark Holmes, vocalist and bassist for the Canadian new wave band Platinum Blonde,
Mark Holmes, writer for the Christian-based television series Gerbert,
Mark Holmes, member of the Los Angeles band Bleed the Dream,
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