K16 may refer to:
HMS K16, a 1916 K class submarine,
K-16 (Kansas highway), a state highway in Kansas,
K-16 (education), a movement in the United States to bring together the various levels of education for younger students,
Kelsey K-16, an American, strut-braced, high-wing, two-seat, glider,
Symphony No. 1 (Mozart), K. 16, by Wolfgang Amadeus Mozart,
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