Isaac Jones may refer to:
Isaac Dashiell Jones, Maryland politician,
Isaac Jones (clergyman) (1804-1850), translator and curate of St Deiniol's Church, Llanddaniel Fab, Wales,
Isaac Jones (sprinter), Gambian sprinter,
Isaac Jones (Philadelphia), Mayor of Philadelphia, Pennsylvania from 1767 to 1769,
Ike Jones (born 1929), American producer and actor and former husband of actress Inger Stevens,
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