, Rendering based on PDB 2KBX.
Ortholog search: PDBe, RCSB
List of PDB id codes
2KBX, 3F6Q, 3IXE, 3KMU, 3KMW, 3REP
ILK; ILK-2; P59
OMIM: 602366 MGI: 1195267 HomoloGene: 3318 ChEMBL: 5247 GeneCards: ILK Gene
• protein serine/threonine kinase activity, • signal transducer activity, • integrin binding, • protein binding, • ATP binding, • SH3 domain binding, • protein kinase binding,
• cytoplasm, • cytosol, • plasma membrane, • cell-cell junction, • focal adhesion, • sarcomere, • lamellipodium, • neuronal cell body, • costamere, • terminal bouton, • dendritic shaft, • protein complex,
• branching involved in ureteric bud morphogenesis, • positive regulation of cell-matrix adhesion, • protein phosphorylation, • negative regulation of protein kinase activity, • cell cycle arrest, • cell-matrix adhesion, • integrin-mediated signaling pathway, • cell aging, • cell proliferation, • positive regulation of cell proliferation, • negative regulation of cardiac muscle cell apoptotic process, • negative regulation of smooth muscle cell migration, • peptidyl-serine phosphorylation, • positive regulation of cell migration, • positive regulation of BMP signaling pathway, • myelin assembly, • regulation of actin cytoskeleton organization, • cell junction assembly, • substrate adhesion-dependent cell spreading, • positive regulation of phosphorylation, • extracellular fibril organization, • positive regulation of MAP kinase activity, • negative regulation of neuron apoptotic process, • establishment or maintenance of epithelial cell apical/basal polarity, • positive regulation of myoblast differentiation, • positive regulation of osteoblast differentiation, • positive regulation of axon extension, • positive regulation of transcription, DNA-dependent, • negative regulation of smooth muscle cell proliferation, • neuron projection morphogenesis, • positive regulation of dendrite morphogenesis, • protein heterooligomerization, • positive regulation of protein kinase B signaling cascade, • positive regulation of canonical Wnt receptor signaling pathway,
Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
6.62 - 6.63 Mb
105.74 - 105.74 Mb
Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, and signal transduction.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.
In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization.
Integrin-linked kinase has been shown to interact with LIMS1,AKT1,ILKAP,ACP6 and parvin.