Cool & Dre are a team of American record producers from Miami, Florida, consisting of Marcello "Cool" Valenzano and Andre "Dre" Christopher Lyon.
The duo started their own record label, Epidemic Records. They signed a contract with Jive Records in 2003 concerning the distribution of their first artist, Dirtbag.
In August 2010, the duo officially partnered with Cash Money Records. In April 2011, the duo signed a deal with Interscope Records through Cash Money (the first time Cash Money is under another Universal label), also to distribute their label Epidemic Records.