- Isaac Castle -- Isaac Matafwani
- Isaac Meyer -- Isaac Wanzama
- Isaac Wardell -- Isabel Mendoza
- Isabel Monar -- Isabella Colbran
- Isabella Ferrari -- Isabelle Chomet
- Isabelle Cornelis -- Isabelle's Gift
- Isabelo -- Isaiah Sheffer
- Isaiah Six -- Isao Suzuki Trio
- Isao Takei -- ish!
- Ish -- 石嶺聡子
- IShine Poetic Lee -- Isidor Achron
- Isidor Alcaide-Backlund -- Isis Project