- Frank Sears
- Frank Sebastian
- Frank Secich
- Frank Seligman
- Frank Sellman
- Frank Selman
- Frank Senior
- Frank Serafine
- Frank Severino
- Frank Seyda
- Frank Shildt
- Frank Shinobi
- Frank Shipway
- Frank Shofner
- Frank Shulte
- Frank Sidebottom
- Frank Signorelli
- Frank Simes
- Frank Simms
- Frank Simon
- Frank Sinatra
- Frank Sinatra, Jr.
- Frank Singer
- Frank Sirius
- Frank Ski
- Frank-Ski
- Frank Skinner
- Frank Slay
- Frank Slay Orchestra
- Frank Smallwood
- Frank Smeekes
- Frank Smith
- Frank Socolow
- Frank Soda & the Imps
- Frank Sokolow
- Frank Solano
- Frank & Somi
- Frank Sonic
- Frank Southecorvo
- Frank Sparks
- Frank Spatula
- Frank Spilker
- Frank "Springback" James
- Frank Stacks
- Frank Stafford
- Frank Stagnitta
- Frank Stallone
- Frank Stanger
- Frank Stanley
- Frank Starr
- Frank Steiner Jr.
- Frank Stella
- Frank & Steve
- Frank Stewart
- Frank Stick
- Frank Sticks
- Frank Stoeckle
- Frank Stokes
- Frank Straass
- Frank Strass
- Frank Strazzeri
- Frank Strobel
- Frank Strozier
- Frank Strozier Sextet
- Frank Struck
- Frank Stuart
- Frank Styles
- Frank Styx A.K.A. Jon Doe
- Frank Suchland
- Frank Sullivan
- Frank Sylvano